本帖最後由 熒惑 於 2010-7-15 18:12 編輯
哇,竟然貼呢單新聞出黎,我唔覆下講唔過去wo:lol
隻 protein 叫做 OC-17, ovocleidin-17,新聞串錯左
Gallus gallus 即係 家雞,學名je
protein structure我貼埋出黎,唔知大學以外既地方睇唔睇到呢?有3個alpha-helices同8個beta-sheets
.....想問有冇人有興趣睇份paper講乜?
J Biol Chem. 2004 Sep 24;279(39):40876-81. Epub 2004 Jul 19.
Crystal structure of ovocleidin-17, a major protein of the calcified Gallus gallus eggshell: implications in the calcite mineral growth pattern.
Reyes-Grajeda JP, Moreno A, Romero A.
Instituto de Quimica, Universidad Nacional Autonoma de Mexico (UNAM) Circuito Exterior, C.U. Mexico, D.F. 04510, Mexico.
Abstract
Ovocleidin-17 (OC17) from Gallus gallus is one of the best candidates to control and regulate the deposition of calcium carbonate in the calcified eggshell layer. Here, the crystal structure of monomeric OC17, determined at a resolution of 1.5 A, was refined to a crystallographic R-factor of 20.1%. This is the first protein directly involved in a non-pathological biomineralization process resolved by x-ray diffraction to date. The protein has a mixed alpha/beta structure containing a single C-type lectin-like domain. However, although OC17 shares the conserved scaffold of the C-type lectins, it does not bind carbohydrates. Nevertheless, in vitro OC17 modifies the crystalline habit of calcium carbonate (CaCO3) and the pattern of crystal growth at intervals of 5-200 microg/ml. Determining the three-dimensional structure of OC17 contributes to a better understanding of the biological behavior of structurally related biomolecules and of the mechanisms involved in eggshell and other mineralization processes.
Copyright 2004 American Society for Biochemistry and Molecular Biology, Inc.
PMID: 15263013 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/15263013 |